The present study involves the scale up studies of lansoprazole delayed release capsules and establishment of uniformity of various scale up parameters, critical process variable assessment. Delayed release capsules of lansoprazole were formulated using drug layering and enteric coating technology for oral administration. Lansoprazole and other excipients are layered around d the sugar spheres with the help of binding agent HPC and sucrose. The drug layered pellets were then coated with enteric coating agent (Eutragit – 3- D-55 in FBP (wurster coating) and subjected to lubrication using talc followed by drying for 4hrs. all the process parameters were validated and the results suggests that the lansoprazole delayed release capsules can be produced in large scale by the validated parameters. The validated parameters can be recommented for execute batch production of lansoprazole delayed release capsules.
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